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1

Potent and selective adenosine A2A receptor antagonists: [1,2,4]-triazolo[4,3-c]pyrimidin-3-ones

Joel M. Harris, Bernard R. Neustadt, Hongtao Zhang, Jean Lachowicz, Mary Cohen-Williams, Geoff Varty, Jinsong Hao, Andrew W. Stamford

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 1.29 MB

english, 2011

2

Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction

Stamford, Andrew W., Scott, Jack D., Li, Sarah W., Babu, Suresh, Tadesse, Dawit, Hunter, Rachael, Wu, Yusheng, Misiaszek, Jeffrey, Cumming, Jared N., Gilbert, Eric J., Huang, Chunli, McKittrick, Brian

Journal:

ACS Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 1.14 MB

english, 2012

3

Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes

Wu, Wen-Lian, Hao, Jinsong, Domalski, Martin, Burnett, Duane A, Pissarnitski, Dmitri, Zhao, Zhiqiang, Stamford, Andrew W, Scapin, Giovanna, Gao, Ying Duo, Soriano, Aileen, Kelly, Terri M, Yao, Zuliang

Journal:

ACS Medicinal Chemistry Letters

Année:

2016

Langue:

english

Fichier:

PDF, 361 KB

english, 2016

4

ChemInform Abstract: Formal Olefination and Acylaziridination of Imidazolones.

Xing Dai, Michael W. Miller, Andrew W. Stamford

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 54 KB

english, 2010

5

BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease. Edited by Varghese John.

Dr. Andrew Stamford

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 124 KB

english, 2011

6

Unambiguous structural characterization of hydantoin reaction products using 2D HMBC NMR spectroscopy

Mary M. Senior, Tze-Ming Chan, Guoqing Li, Ying Huang, Andrew Stamford

Journal:

Magnetic Resonance in Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 227 KB

english, 2007

7

Diaryl piperidines as CB1 receptor antagonists

Jack D. Scott, Sarah W. Li, Hongwu Wang, Yan Xia, Charles L. Jayne, Michael W. Miller, Ruth A. Duffy, George C. Boykow, Timothy J. Kowalski, Brian D. Spar, Andrew W. Stamford, Samuel Chackalamannil, J

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 992 KB

english, 2010

8

Highly potent and selective inhibitors of endothelin converting enzyme

Samuel Chackalamannil, Shin Chung, Andrew W. Stamford, Brian A. McKittrick, Yuguang Wang, Hsingan Tsai, Reneé Cleven, Ahmad Fawzi, Michael Czarniecki

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1996

Langue:

english

Fichier:

PDF, 179 KB

english, 1996

9

Design and synthesis of phosphinic acids that triply inhibit endothelin converting enzyme, angiotensin converting enzyme and neutral endopeptidase 24.11

Brian A. McKittrick, Andrew W. Stamford, Xiaoyu Weng, Ke Ma, Samuel Chackalamannil, Michael Czarniecki, ReneéM. Cleven, Ahmad B. Fawzi

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1996

Langue:

english

Fichier:

PDF, 304 KB

english, 1996

10

Discovery of novel orally active ureido NPY Y5 receptor antagonists

Guoqing Li, Andrew W. Stamford, Ying Huang, Kuo-Chi Cheng, John Cook, Constance Farley, Jun Gao, Lorraine Ghibaudi, William J. Greenlee, Mario Guzzi, Margaret van Heek, Joyce J. Hwa, Joe Kelly, Deborr

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 171 KB

english, 2008

11

Potent and selective adenosine A2A receptor antagonists: 1,2,4-Triazolo[1,5-c]pyrimidines

Bernard R. Neustadt, Hong Liu, Jinsong Hao, William J. Greenlee, Andrew W. Stamford, Carolyn Foster, Leyla Arik, Jean Lachowicz, Hongtao Zhang, Rosalia Bertorelli, Silva Fredduzzi, Geoffrey Varty, Mar

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 199 KB

english, 2009

12

Tetrahydroquinoline sulfonamides as vasopressin 1b receptor anatgonists

Jack D. Scott, Michael W. Miller, Sarah W. Li, Sue-Ing Lin, Henry A. Vaccaro, Liwu Hong, Deborra E. Mullins, Mario Guzzi, Jay Weinstein, Robert A. Hodgson, Geoffrey B. Varty, Andrew W. Stamford, Tin-Y

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2009

13

Discovery of a nortropanol derivative as a potent and orally active GPR119 agonist for type 2 diabetes

Yan Xia, Samuel Chackalamannil, William J. Greenlee, Charles Jayne, Bernard Neustadt, Andrew Stamford, Henry Vaccaro, Xiaoying (Lucy) Xu, Hana Baker, Kim O’Neill, Morgan Woods, Brian Hawes, Tim Kowals

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 2.17 MB

english, 2011

14

An unusual contra-Michael addition of NaNO2–ceric ammonium nitrate to acrylic esters

Alexei V. Buevich, Yusheng Wu, Tze-Ming Chan, Andrew Stamford

Journal:

Tetrahedron Letters

Année:

2008

Langue:

english

Fichier:

PDF, 160 KB

english, 2008

15

Synthesis of o-indan[1.1.1]cyclophane and potential indanyl subunits of the fullerenes

Philip Magnus, David Witty, Andrew Stamford

Journal:

Tetrahedron Letters

Année:

1993

Langue:

english

Fichier:

PDF, 221 KB

english, 1993

16

Design and synthesis of xanthine analogues as potent and selective PDE5 inhibitors

Yuguang Wang, Samuel Chackalamannil, Zhiyong Hu, Craig D Boyle, Claire M Lankin, Yan Xia, Ruo Xu, Theodros Asberom, Dmitri Pissarnitski, Andrew W Stamford, William J Greenlee, Jeffrey Skell, Stanley K

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2002

Langue:

english

Fichier:

PDF, 158 KB

english, 2002

17

The Gif system as a tool in medicinal chemistry: The oxidation of Sch 57726 under GoAggIII conditions

Darío Doller, Samuel Chackalamannil, Andrew Stamford, Brian McKittrick, Michael Czarniecki

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1997

Langue:

english

Fichier:

PDF, 368 KB

english, 1997

18

Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists

Ho-Sam Ahn, Leyla Arik, George Boykow, Duane A. Burnett, Mary Ann Caplen, Michael Czarniecki, Martin S. Domalski, Carolyn Foster, Mahua Manna, Andrew W. Stamford, Yusheng Wu

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1999

Langue:

english

Fichier:

PDF, 262 KB

english, 1999

19

Optimization of purine based PDE1/PDE5 inhibitors to a potent and selective PDE5 inhibitor for the treatment of male ED

Craig D. Boyle, Ruo Xu, Theodros Asberom, Samuel Chackalamannil, John W. Clader, William J. Greenlee, Henry Guzik, Yuequing Hu, Zhiyong Hu, Claire M. Lankin, Dmitri A. Pissarnitski, Andrew W. Stamford

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 141 KB

english, 2005

20

Potent, selective, and orally active adenosine A2A receptor antagonists: Arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines

Bernard R. Neustadt, Jinsong Hao, Neil Lindo, William J. Greenlee, Andrew W. Stamford, Deen Tulshian, Ennio Ongini, John Hunter, Angela Monopoli, Rosalia Bertorelli, Carolyn Foster, Leyla Arik, Jean L

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 170 KB

english, 2007

21

Renal Effects of SCH 54470: A Triple Inhibitor of ECE, ACE, and NEP

Subbarao Vemulapalli, Madhu Chintala, Andrew Stamford, Robert Watkins, Peter Chiu, Edmund Sybertz, Ahmad B. Fawzi

Journal:

Cardiovascular Therapeutics

Année:

1997

Langue:

english

Fichier:

PDF, 616 KB

english, 1997

22

Identification and characterization of pseudoirreversible nonpeptide antagonists of the neuropeptide Y Y5 receptor and development of a novel Y5-selective radioligand

Deborra Mullins, Nika Adham, David Hesk, Yusheng Wu, Joseph Kelly, Ying Huang, Mario Guzzi, Xiaoping Zhang, Stuart McCombie, Andrew Stamford, Eric Parker

Journal:

European Journal of Pharmacology

Année:

2008

Langue:

english

Fichier:

PDF, 807 KB

english, 2008

23

On the power of super acid—iodination of aromatic ring in the presence of imidazole moiety of the potent gamma secretase modulators (GSM) en route to tritium labeling

Mihirbaran Mandal, Carolee Lavey, Alexei V. Buevich, Zhaoning Zhu, Andrew W. Stamford, Xiaoxiang Liu

Journal:

Tetrahedron Letters

Année:

2012

Langue:

english

Fichier:

PDF, 474 KB

english, 2012

24

Inhibition of cellular action of thrombin by N3-cyclopropyl-7-{[4-(1-methylethyl)phenyl]methyl}-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist

Ho-Sam Ahn, Carolyn Foster, George Boykow, Andrew Stamford, Mahua Manna, Michael Graziano

Journal:

Biochemical Pharmacology

Année:

2000

Langue:

english

Fichier:

PDF, 472 KB

english, 2000

25

An assessment of the cerebroprotective potential of volatile anaesthetics using two independent methods in an in vitro model of cerebral ischaemia

Christopher C Toner, Andrew J Milne, Karen L Blatchford, Daniel P McLaughlin, Jonathan A Stamford

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 687 KB

english, 2002

26

Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status

Eric Parker, Margaret Van Heek, Andrew Stamford

Journal:

European Journal of Pharmacology

Année:

2002

Langue:

english

Fichier:

PDF, 209 KB

english, 2002

27

Characterization of human, dog and rabbit corpus cavernosum type 5 phosphodiesterases

Peng Wang, Ping Wu, Joyce G. Myers, Andrew Stamford, Robert W. Egan, M.Motasim Billah

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 139 KB

english, 2001

28

Chronic BACE inhibition halts further age-related increases in brain Aß and amyloid plaques in aged TgCRND8 mice with established plaques

Lynn Hyde, Cinzia Cantu, Bonnie Werner, Xia Chen, Marie Sondey, Maxine Chen, Blair Weig, Abigail LaShomb, Sherry Lu, Robert Hodgson, Jack Scott, Jared Cumming, Andrew Stamford, Eric Parker, Matthew Ke

Journal:

Alzheimer's & Dementia

Année:

2012

Langue:

english

Fichier:

PDF, 61 KB

english, 2012

29

Chronic BACE inhibition dramatically slows the rate of Aß accumulation and the development of amyloid plaques in young TgCRND8 mice

Lynn Hyde, Xia Chen, Lindsay Stahl, Marie Sondey, Jack Scott, Jared Cumming, Andrew Stamford, Eric Parker, Matthew Kennedy

Journal:

Alzheimer's & Dementia

Année:

2012

Langue:

english

Fichier:

PDF, 60 KB

english, 2012

30

A Novel Method for the Preparation of 4-Arylimidazolones

DeMong, Duane E., Ng, Irene, Miller, Michael W., Stamford, Andrew W.

Journal:

Organic Letters

Année:

2013

Langue:

english

Fichier:

PDF, 453 KB

english, 2013

31

Inhibitors of BACE for treating Alzheimer's disease: a fragment-based drug discovery story

Stamford, Andrew, Strickland, Corey

Journal:

Current Opinion in Chemical Biology

Année:

2013

Langue:

english

Fichier:

PDF, 2.26 MB

english, 2013

32

The emergency urology ‘tool-box’: a useful adjunct for the urology trainee?

Chetwood, Andrew, Stamford, Rosie, Nair, Rajesh

Journal:

BJU International

Année:

2013

Langue:

english

Fichier:

PDF, 126 KB

english, 2013

33

Characterization of a novel vasopressin V1b receptor antagonist, V1B-30N, in animal models of anxiety-like and depression-like behavior

Hodgson, Robert A., Mullins, Deborra, Lu, Sherry X., Guzzi, Mario, Zhang, Xiaoping, Bleickardt, Carina J., Scott, Jack D., Miller, Michael W., Stamford, Andrew W., Parker, Eric M., Varty, Geoffrey B.

Journal:

European Journal of Pharmacology

Année:

2014

Langue:

english

Fichier:

PDF, 986 KB

english, 2014

34

Chronic administration of a novel BACE inhibitor reduced brain Aβ levels and mature plaques and modestly improved cognition in transgenic CRND8-APPswe/ind mice

Hyde, Lynn A., Del Vecchio, Robert A., Kazdoba, Tatiana M., Manning, Ronald, Terracina, Giuseppe, Zhang, Qi, Babu, Suresh, Guo, Tao, Tadese, Dawit, Zhang, Lili, Parker, Eric M., Stamford, Andrew W., K

Journal:

Alzheimer's & Dementia

Année:

2010

Langue:

english

Fichier:

PDF, 49 KB

english, 2010

35

Pharmacological characterization of novel iminoheterocyclic BACE1 inhibitors for the treatment of Alzheimer's disease

Kennedy, Matthew E., Chen, Xia, Kuvelkar, Reshma, Cumming, Jared, Iserloh, Ulrich, McKittrick, Brian, Pan, Janping, Smith, Elizabeth, Sun, Zhong-Yue, Stamford, Andrew, Zhu, Zhaoning, Beyer, Brian, Str

Journal:

Alzheimer's & Dementia

Année:

2010

Langue:

english

Fichier:

PDF, 47 KB

english, 2010

36

Synthesis of the antitumor bisindole alkaloid vinblastine: diastereoselectivity and solvent effect on the stereochemistry of the crucial C-15-C-18' bond

Magnus, Philip, Stamford, Andrew, Ladlow, Mark

Journal:

Journal of the American Chemical Society

Année:

1990

Langue:

english

Fichier:

PDF, 308 KB

english, 1990

37

The Discovery of N -((2 H -Tetrazol-5-yl)methyl)-4-(( R )-1-((5 r ,8 R )-8-( tert -butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): A Potent and Selective Glucagon Receptor Antagonist

DeMong, Duane, Dai, Xing, Hwa, Joyce, Miller, Michael, Lin, Sue-Ing, Kang, Ling, Stamford, Andrew, Greenlee, William, Yu, Wensheng, Wong, Michael, Lavey, Brian, Kozlowski, Joseph, Zhou, Guowei, Yang,

Journal:

Journal of Medicinal Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 529 KB

english, 2014

38

Nonoxidative coupling methodology for the synthesis of the antitumor bisindole alkaloid vinblastine and a lower-half analog: solvent effect on the stereochemistry of the crucial C-15/C-18' bond

Magnus, Philip, Mendoza, Jose S., Stamford, Andrew, Ladlow, Mark, Willis, Paul

Journal:

Journal of the American Chemical Society

Année:

1992

Langue:

english

Fichier:

PDF, 1.79 MB

english, 1992

39

Formal Olefination and Acylaziridination of Imidazolones †

Dai, Xing, Miller, Michael W., Stamford, Andrew W.

Journal:

Organic Letters

Année:

2010

Langue:

english

Fichier:

PDF, 647 KB

english, 2010

40

Convenient route to γ-nitro-α-amino acids: conjugate addition of nitroalkanes to dehydroalanine derivatives

Crossley, Maxwell J., Fung, Yik M., Potter, Jeffrey J., Stamford, Andrew W.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Année:

1998

Langue:

english

Fichier:

PDF, 152 KB

english, 1998

41

[Annual Reports in Medicinal Chemistry] Annual Reports in Medicinal Chemistry Volume 37 Volume 37 || Chapter 6. Phosphodiesterase 5 inhibitors

Stamford, Andrew W

Année:

2002

Langue:

english

Fichier:

PDF, 743 KB

english, 2002

42

Discovery of the oxazabicyclo[3.3.1]nonane derivatives as potent and orally active GPR119 agonists

Dai, Xing, Stamford, Andrew, Liu, Hong, Neustadt, Bernard, Hao, Jingsong, Kowalski, Tim, Hawes, Brian, Xu, Xiaoying, Baker, Hana, O’Neill, Kim, Woods, Morgan, Tang, Huadong, Greenlee, William

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2015

Langue:

english

Fichier:

PDF, 1.17 MB

english, 2015

43

[Annual Reports in Medicinal Chemistry] Volume 34 || Chapter 4. Recent Advances in the Development of Neuropeptide Y Receptor Antagonists

Stamford, Andrew W.

Année:

1999

Langue:

english

Fichier:

PDF, 800 KB

english, 1999

44

ChemInform Abstract: A Novel Method for the Preparation of 4-Arylimidazolones.

DeMong, Duane E., Ng, Irene, Miller, Michael W., Stamford, Andrew W.

Journal:

Année:

2013

Fichier:

PDF, 28 KB

2013

45

Biosynthesis of vitamin B12: the preparative multi-enzyme synthesis of precorrin-3A and 20-methylsirohydrochlorin (a 2,7,20-trimethylisobacteriochlorin)

STAMFORD, N. J. Patrick, CROUZET, Joël, CAMERON, Béatrice, ALANINE, Alex I. D., PITT, Andrew R., YELISEEV, Alexei A., BATTERSBY, Alan R.

Journal:

Biochemical Journal

Année:

1996

Langue:

english

Fichier:

PDF, 450 KB

english, 1996

46

[Annual Reports in Medicinal Chemistry] Volume 38 || Chapter 7. Recent developments in neuropeptide Y receptor modulators

Stamford, Andrew W.

Année:

2003

Langue:

english

Fichier:

PDF, 835 KB

english, 2003

47

Attitudes Towards Data Collection, Ownership and Sharing Among Patients with Parkinson’s Disease

Mursaleen, Leah Rose, Stamford, Jon Andrew, Jones, David Ashford, Windle, Richard, Isaacs, Tom

Journal:

Journal of Parkinson s Disease

Année:

2017

Langue:

english

Fichier:

PDF, 311 KB

english, 2017

48

Discovery of MK-8282 as a potent G-Protein-Coupled Receptor 119 agonist for the treatment of Type 2 Diabetes

Neelamkavil, Santhosh Francis, Stamford, Andrew W., Kowalski, Timothy, Biswas, Dipshikha, Boyle, Craig, Chackalamannil, Samuel, Xia, Yan, Jayne, Charles, Neustadt, Bernard, Hao, Jinsong, Liu, Hong, Da

Journal:

ACS Medicinal Chemistry Letters

Année:

2018

Langue:

english

Fichier:

PDF, 378 KB

english, 2018